Stanislav Kalinin
Kuopio
Summary
Strong collaborator comfortable working with contractors, vendors, engineers and staff at all levels. Capable leader motivating and training teams in research procedures, mentoring for achievement. Research Assistant recognized as main point of contact to resolve issues within research and testing environments. Dedicated professional providing exceptional support with necessary functions throughout manufacturing research processes. Resourceful professional offering skills in complex problem resolution involving synthesis, formulation, processes, testing and root cause.
Overview
2
2
years of professional experience
Work History
Research engineer
Laboratory of Chemical Pharmacology
- Design, synthesis, computer-aided and biological investigation of isoform-selective human Carbonic Anhydrase inhibitors.
Visiting researcher
Neurofarba Department
- Inhibitory profiling of small molecules using stopped-flow technique and recombinant proteins.
Research engineer
Pharma Technology Transfer Center
- Scaling up pharmaceutical manufacturing
- In vitro evaluation of compounds biological activity.
Research engineer
Chemogenomics Institute
- Synthesis of 1,4-oxazepine-based tetracyclic systems via original tandem condensation strategy.
Postdoctoral Researcher
University Of Eastern Finland, School Of Pharmacy
2021.09 - Current
- Designed research projects and alternative approaches and discussed results with professor.
- Contributed to and actively participated in research conception, design and execution to address defined problems.
- Leveraged interpersonal and communication skills to mentor PhD, graduate and undergraduate students.
- Drafted manuscripts and presented findings at major 3 research conferences.
- Completed analysis of data acquired from research and verified careful documentation of information.
Education
PhD - Medicinal Chemistry
Institute of Physiologically Active Compounds (IPAC), Russian Academy of Science
12.2019
M. Sc. - Chemistry (Subject Teacher and Researcher education)
Saint-Petersburg State University
Saint-Petersburg, Russia01.2016
B. Sc. - Chemistry (Subject Teacher and Researcher education)
Yaroslavl State Pedagogic University
Yaroslavl, Russia01.2014
Skills
- Sample Collection
- Team Collaboration
- Synthesis and Formulation
- Data Quality Control
- Computer Modeling
- Project Management
- Technical Documentation
- Staff Leadership
- Research and Analysis
- Staff Training
- Laboratory Experiments
- Verbal Communication
- Recordkeeping Accuracy
Accomplishments
- Discovered a [Name] process utilized in strengthening materials utilized in [Name].
- Trained [Number] staff on multiple research projects.
- Engaged in an extensive, in-house, multi-scale research and development study.
- Major Projects Include [Describe Projects]
Research Activity
- Research engineer, Laboratory of Chemical Pharmacology, Saint-Petersburg State University, Saint-Petersburg, Russia, 2016
- Visiting researcher, Neurofarba Department, University of Florence, Florence, Italy, 2016
- Research engineer, Pharma Technology Transfer Center, Yaroslavl State Pedagogic University, Yaroslavl, Russia, 2014, 2016
- Research engineer, Chemogenomics Institute, Yaroslavl State Pedagogic University, Yaroslavl, Russia, 2011, 2014
Teaching Activity
- Supervisor of three B. Sc. interns, Saint-Petersburg State University, Saint-Petersburg, Russia, 2016, 2019
- Teaching assistant, Yaroslavl State Pedagogic University, Yaroslavl, Russia, 2016
Conference Presentations
- Design and synthesis of isoform-selective carbonic anhydrase inhibitors for biomedical application, The IV satellite meeting on Carbonic Anhydrases (CASM-2019), Parma, Italy, 11/2019
- Design and synthesis of human Carbonic Anhydrase II inhibitors for conjugation with biopolimeric nanoparticles, II international conference “Modern Synthetic Methodologies for Creating Medicines and Functional Materials” (MOSM 2018), Yekaterinburg, Russia, 11/2018
- Direct sulfochlorination of heterocycles as a speedy entry into isoform-selective Carbonic Anhydrase Inhibitors, The III satellite meeting on Carbonic Anhydrases (CASM-2017), Montecatini, Italy, 05/2017
Honors And Awards
- Analit-Shimadzu Personal award for PhD-students, 2019
- Yaroslavl Region Governor award, 2015
- Russian Federation President’s award, 2013
Personal Information
- Place of Birth: Yaroslavl, Russia
- Date of Birth: 02/22/92
Publications
Further validation of Strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement, J. Enzyme Inhib. Med. Chem., 2020, 35, 165-171, M.Krasavin, S.Kalinin, S.Zozulya, A.Gryniukova, P.Borysko, A.Angeli, C.T.Supuran Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry, J. Enzyme Inhib. Med. Chem., 2020, 35, 306-310, M.Krasavin, S.Kalinin, S.Zozulya, A.Gryniukova, P.Borysko, A.Angeli, C.T.Supuran Highly Hydrophilic 1,3-Oxazol-5-yl Benzenesulfonamide Inhibitors of Carbonic Anhydrase II for Reduction of Glaucoma-Related Intraocular Pressure, Bioorganic and Medicinal Chemistry, 2019, 27, 115086, S.Kalinin, A.Valtari, A.Ruponen, E.Toropainen, A.Kovalenko, A.Nocentini, M.Gureev, D.Dar'in, A.Urtti, C.T.Supuran, M.Krasavin From random to rational: A Discovery Approach to Selective Subnanomolar Inhibitors of Human Carbonic Anhydrase IV Based on the Castagnoli-Cushman Multicomponent Reaction, European Journal of Medicinal Chemistry, 2019, 182, 111642, S.Kalinin, A.Nocentini, A.Kovalenko, V.Sharoyko, A.Bonardi, A.Angeli, P.Gratteri, T.B.Tennikova, C.T.Supuran, M.Krasavin Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines, European Journal of Medicinal Chemistry, 2019, 168, 301-314, M.Krasavin, A.Shetnev, S.Baykov, S.Kalinin, A.Nocentini, V.Sharoyko, G.Poli, T.Tuccinardi, M.Korsakov, T.B.Tennikova, C.T.Supuran 1,2,4-Oxadiazole/2-imidazoline hybrids: Multi-target-directed compounds for the treatment of infectious diseases and cancer, Int. J. Mol. Sci., 2019, 20, 1699, A.Shetnev, S.Baykov, S.Kalinin, A.Belova, V.Sharoyko, A.Rozhkov, L.Zelenkov, M.Tarasenko, E.Sadykov, M.Korsakov, M.Krasavin Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment, European Journal of Medicinal Chemistry, 2019, 164, 92-105, M.Krasavin, A.Shetnev, T.Sharonova, S.Baykov, S.Kalinin, A.Nocentini, V.Sharoyko, G.Poli, T.Tuccinardi, S.Presnukhina, T.B.Tennikova, C.T.Supuran Unprotected primary sulfonamide group facilitates ring-forming cascade en route to polycyclic [1.4]oxazepine-based carbonic anhydrase inhibitors, Bioorganic Chemistry, 2018, 76, 140-146, A.Sapegin, S.Kalinin, A.Angeli, C.T.Supuran, M.Krasavin Heterocyclic Periphery in the Design of Carbonic Anhydrase Inhibitors: 1,2,4-Oxadiazol-5-yl Benzenesulfonamides as Potent and Selective Inhibitors of Cytosolic hCA II and Membrane-Bound hCA IX Isoforms, Bioorganic Chemistry, 2018, 76, 88-97, M.Krasavin, A.Shetnev, T.Sharonova, S.Baykov, T.Tuccinardi, S.Kalinin, A.Angeli, C.T.Supuran The first one-pot ambient-temperature synthesis of 1,2,4-oxadiazoles from amidoximes and carboxylic acid esters, Tetrahedron, 2017, 73, 945-951, S.Baykov, T.Sharonova, A.Shetnev, S.Rozhkov, S.Kalinin, A.V.Smirnov Primary mono- and bis-sulfonamides obtained via regiospecific sulfochlorination of N-arylpyrazoles: inhibition profile against a panel of human carbonic anhydrases, Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32, 920-934, M.Krasavin, M.Korsakov, O.Ronzhina, T.Tuccinardi, S.Kalinin, M.Tanç, C.T.Supuran Human carbonic anhydrase inhibitory profile of mono- and bis-sulfonamides synthesized via a direct sulfochlorination of 3-and 4-(hetero)arylisoxazol-5-amine scaffolds, Bioorganic and Medicinal Chemistry, 2017, 25, 1914-1925, M.Krasavin, M.Korsakov, Z.Zvonaryova, E.Semyonychev, T.Tuccinardi, S.Kalinin, M.Tanç, C.T.Supuran Synthesis, structure and properties of N-aminosaccharin - A selective inhibitor of human carbonic anhydrase I, Tetrahedron Letters, 2017, 58, 172-174, M.A.Kuznetsov, A.N.Shestakov, M.Zibinsky, M.Krasavin, C.T.Supuran, S.Kalinin, M.Tanç Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII, ACS Medicinal Chemistry Letters, 2017, 8, 1105-1109, S.Kalinin, S.Kopylov, T.Tuccinardi, A.Sapegin, D.Dar'in, A.Angeli, C.T.Supuran, M.Krasavin Isoform-selective inhibitory profile of 2-imidazoline-substituted benzenesulfonamides against a panel of human carbonic anhydrases, Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31, 197-202, C.T.Supuran, S.Kalinin, M.Tanç, P.Sarnpitak, P.Mujumdar, S.-A.Poulsen, M.Krasavin Multicomponent chemistry in the synthesis of carbonic anhydrase inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31, 185-199, S.Kalinin, C.T.Supuran, M.Krasavin Efficient Use of 1,2-Dihaloazine Synthons in Transition Metal-Free Preparation of Diverse Heterocycle-Fused 1,4-Oxazepines, Eur. J. Org. Chem., 2015, 1333-1340, A.Sapegin, S.Kalinin, A.Smirnov, M.Dorogov, M.Krasavin New tetracyclic 1,4-oxazepines constructed via practically simple tandem condensation strategy from readily available synthons, Tetrahedron, 2014, 70, 1077-1083, A.Sapegin, S.Kalinin, A.Smirnov, M.Dorogov, M.Krasavin Dibenzo[b,f]pyrazolo[1,5-d][1,4]oxazepines: a facile construction of a rare heterocyclic system via tandem aromatic nucleophilic substitution - Smiles rearrangement – denitrocyclization, Synthesis, 2012, 44, 2401-2407, A.Sapegin, S.Kalinin, A.Smirnov, M.Dorogov, M.Krasavin
Languages
Russian
Native language
English
Advanced
C1
German
Intermediate
B1
Italian
Elementary
A2
Timeline
Postdoctoral Researcher
University Of Eastern Finland, School Of Pharmacy
2021.09 - Current
Research engineer
Laboratory of Chemical Pharmacology
Visiting researcher
Neurofarba Department
Research engineer
Pharma Technology Transfer Center
Research engineer
Chemogenomics Institute
PhD - Medicinal Chemistry
Institute of Physiologically Active Compounds (IPAC), Russian Academy of Science
M. Sc. - Chemistry (Subject Teacher and Researcher education)
Saint-Petersburg State University
B. Sc. - Chemistry (Subject Teacher and Researcher education)
Yaroslavl State Pedagogic University
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